Jörg Felsberg Selected Research

O-(6)-methylguanine

1/2021	Telomerase reverse transcriptase promoter mutation- and O6-methylguanine DNA methyltransferase promoter methylation-mediated sensitivity to temozolomide in isocitrate dehydrogenase-wild-type glioblastoma: is there a link?
4/2017	Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma.
8/2007	Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma.
1/2005	Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.

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Jörg Felsberg Research Topics

Disease

40	Neoplasms (Cancer) 01/2022 - 10/2002
34	Glioma (Gliomas) 08/2022 - 01/2005
31	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 10/2002
21	Astrocytoma (Pilocytic Astrocytoma) 10/2021 - 10/2002
5	Medulloblastoma 07/2014 - 04/2009
4	Brain Neoplasms (Brain Tumor) 01/2020 - 12/2008
3	Neoplasm Metastasis (Metastasis) 01/2022 - 02/2012
3	Ependymoma 08/2021 - 06/2011
3	Oligodendroglioma 02/2016 - 01/2005
2	Residual Neoplasm 04/2017 - 05/2012
2	Intellectual Disability (Idiocy) 01/2017 - 01/2012
2	Infections 01/2016 - 07/2012
2	Disease Progression 02/2015 - 12/2009
2	Neuroepithelial Neoplasms (Gliomatosis Cerebri) 09/2011 - 10/2002
1	Stroke (Strokes) 01/2021
1	Clinical Deterioration 01/2021
1	Melanoma (Melanoma, Malignant) 01/2020
1	Rhabdoid Tumor (Rhabdoid Tumors) 01/2018
1	Pituitary Neoplasms (Pituitary Adenoma) 01/2018
1	Thalassemia 01/2017
1	Familial ependymoma 04/2016
1	Primitive Neuroectodermal Tumors (PNET) 02/2016
1	Invasive Fungal Infections 01/2016
1	Meningioma (Meningiomas) 03/2015
1	Carcinogenesis 06/2014
1	Thrombocytopenia (Thrombopenia) 07/2012
1	Lymphopenia (Lymphocytopenia) 07/2012
1	Neutropenia 07/2012

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 12/2018 - 01/2005
14	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2005
12	Temozolomide (Temodar)FDA LinkGeneric 10/2021 - 08/2007
12	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2021 - 10/2009
11	Messenger RNA (mRNA)IBA 06/2014 - 01/2005
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2008
7	MethyltransferasesIBA 01/2021 - 01/2005
5	Tyrosine (L-Tyrosine)FDA Link 10/2021 - 04/2011
4	O-(6)-methylguanineIBA 01/2021 - 01/2005
4	Alkylating AgentsIBA 03/2020 - 07/2007
4	Biological ProductsIBA 12/2018 - 10/2012
4	ErbB Receptors (EGF Receptor)IBA 11/2017 - 10/2002
4	AcidsIBA 02/2015 - 05/2010
3	Lomustine (CCNU)FDA Link 01/2021 - 12/2009
3	RNA (Ribonucleic Acid)IBA 12/2020 - 08/2012
3	ChromatinIBA 12/2020 - 01/2012
3	Codon (Codons)IBA 12/2018 - 04/2010
3	Histones (Histone)IBA 12/2018 - 01/2012
3	Procarbazine (Matulane)FDA Link 09/2011 - 10/2002
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021 - 01/2017
2	LigandsIBA 01/2020 - 12/2008
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020 - 02/2016
2	Pharmaceutical PreparationsIBA 04/2018 - 12/2008
2	MicroRNAs (MicroRNA)IBA 06/2014 - 01/2014
2	O(6)-Methylguanine-DNA MethyltransferaseIBA 08/2013 - 12/2009
2	Mitogen-Activated Protein KinasesIBA 08/2013 - 02/2010
2	EnzymesIBA 07/2013 - 07/2012
2	Amino Acids FDA Link 07/2013 - 02/2013
2	Decitabine FDA Link 08/2012 - 06/2012
2	Carrier Proteins (Binding Protein)IBA 05/2011 - 04/2011
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2011 - 04/2011
2	NestinIBA 03/2011 - 02/2011
2	Vincristine (Oncovin)FDA LinkGeneric 12/2009 - 10/2002
2	hydrogen sulfite (bisulfite)IBA 08/2007 - 07/2007
1	GlutaredoxinsIBA 01/2022
1	Lactate Dehydrogenase 5IBA 01/2022
1	Irinotecan (Camptosar)FDA LinkGeneric 03/2020
1	Bevacizumab (Avastin)FDA Link 03/2020
1	indolamineIBA 01/2020
1	LGK974IBA 04/2018
1	Protein Isoforms (Isoforms)IBA 04/2018
1	Aldehyde DehydrogenaseIBA 04/2018
1	beta CateninIBA 04/2018
1	Caspase 9IBA 01/2018
1	epidermal growth factor receptor VIIIIBA 11/2017
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2017
1	TensinsIBA 01/2017
1	L 644711 (B-3(+))IBA 05/2015
1	LuciferasesIBA 01/2014
1	TCF Transcription FactorsIBA 01/2014
1	3' Untranslated Regions (3' UTR)IBA 01/2014
1	CytosineIBA 08/2013
1	PeroxiredoxinsIBA 08/2013
1	GuanineIBA 08/2013
1	Phosphates (Orthophosphate)IBA 08/2013
1	Glutamic Acid (Glutamate)FDA Link 07/2013
1	Branched-Chain Amino AcidsIBA 07/2013
1	branched-chain-amino-acid transaminaseIBA 07/2013
1	Dimenhydrinate (DMH)FDA LinkGeneric 08/2012
1	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 06/2012
1	HeterochromatinIBA 01/2012

Therapy/Procedure

20	Drug Therapy (Chemotherapy) 08/2022 - 10/2002
15	Therapeutics 01/2022 - 12/2008
10	Radiotherapy 08/2022 - 10/2002
6	Chemoradiotherapy 08/2021 - 10/2008
1	Immunotherapy 01/2020
1	Ligation 01/2018
1	Maintenance Chemotherapy 04/2017
1	Organ Transplantation 01/2016
1	Combined Modality Therapy 02/2015
1	Operative Surgical Procedures 02/2015
1	Salvage Therapy 09/2012